The Confederation Bridge was closed Sunday to accommodate thousands of runners for the 35th annual Terry Fox Run.

It was the third time the fundraiser has been held on the bridge, with a stream of people running in both directions.

Organizers say about 6,000 runners took part.

“It’s got to be one of the biggest Terry Fox runs in Canada,” said one participant.

Darrell Fox, Terry Fox’s brother, attended the run over the Northumberland Straight for the first time.

“I can't express in words how exciting it is to take all this in,” said Fox. “It’s hard not to think about Terry on a daily basis when he is your brother, but it is amplified that much more on a day like this when we're united.”

Cancer survivor Jeremy Fowler says the run is always a special day for him.

“Throughout the process, Terry Fox was a real inspiration for me to get through it,” he said.

Terry Fox runs are held in 125 communities around the region. Another large event was held Sunday at Point Pleasant Park in Halifax.

It seems everywhere you look, people have a connection to Fox.

“Terry was diagnosed with cycoma, which is what my sister was diagnosed with,” said participant Jennifer Snowbridge. “So for the past three years team Heather Hope has participated in this walk.”

“My mother had breast cancer and I’m cancer researcher at Dalhousie, and I have benefited with some of the funds from the foundation and institute,” said volunteer Krysta Coyle.

Hundreds of millions of dollars have been raised over the 35years to find a cure for the disease.

With files from CTV Atlantic’s Nick Moore.